The culture was first exposed to EGTA to disrupt intercellular tight junctions 31thereby allowing the virus access to its major receptor, present mainly on the basolateral membrane. The opportunities we advance take the form of new drug candidates, regenerative therapeutics, personalized diagnostics, medical devices for the detection or treatment of disease, and software for treatment management. Mouse lungs were formalin-fixed as described previously Discussion If airway epithelial cells can be transduced by a vector expressing Cftrcorrection of a fraction of defective cells may suffice for effective gene therapy. Wickham, T. CF is caused by recessive mutations in the CF transmembrane conductance regulator Cftr gene, which encodes a membrane chloride channel present in the epithelium of many organs 1. I look forward to working with our partners and other stakeholders to broaden our impact. Our office continues to build commercialization capacity, attract new talent for technology development, and generate increasing returns for inventors and UHN.
Martin Haardt of University Health Network, Toronto (UHN) | Read 14 publications | Contact Martin Haardt. University Health Network includes Toronto General and Toronto Western Hospitals, Princess Margaret Cancer Centre, and Toronto Rehabilitation Institute.
Looking For A Professional Download PDF Documents Platform
Martin Haardt's email address m******@ | Show email & phone Senior Patent and Intellectual Property Manager @ University Health Network.
The vector expresses cystic fibrosis transmembrane conductance regulator Cftr using control elements from cytokeratin The relationship between the Cftr mutation and CF lung disease, however, is not clear 2. Left Sections of trachea a and bbronchiole c and dalveoli eand bronchiole g were probed with antibody against VSV-G, detected with rhodamine-conjugated secondary antibody.
Rosenfeld, M. More magazines by this user. Morbidity and mortality in CF patients is chiefly due to lung disease and is characterized by inflammation, obstructive mucus, and persistent infection. Cross sections of cells on culture membranes were probed with antibody against hCFTR, detected with rhodamine-conjugated secondary antibody.
Alumni US Universität Konstanz, Germany
TIRE KINGDOM MIAMI LAKES 57TH
|Close Flag as Inappropriate.
Twenty-eight days after vector delivery, we still could detect signal in bronchioles Fig. Cross sections of cells on culture membranes were probed with antibody against hCFTR, detected with rhodamine-conjugated secondary antibody.
Unlike the normal and Cftr knockout mice used in this study, CF patients have a thickened airway mucus that constitutes an additional vector barrier. In the lung, K18like Cftris expressed in the epithelium of large airways and bronchioles and in submucosal glands, but little is expressed in the alveoli 10 Ng, P.
Adenovirus-neutralizing antibodies in the airway surface liquid also could be problematic, possibly requiring host immunomodulation 33 or shielding the adenovirus coat from antibody recognition through chemical modification 34 or lipid encapsulation
Andrew Roberts. Licensing & Commercialization Associate. Allison Aab.
Video: Martin haardt uhn Hochschule Bonn-Rhein-Sieg VDMA 2013
Manager, Research Planning & Operations. Andrea Berenbaum. IP Lead. Martin Haardt.
Signal was observed in the region of tracheal submucosal glands, but staining to identify positive cells was inconclusive data not shown. Toietta, G. We think the development of a vector without the tag will rectify this potential problem. Acute inflammation was minimal to moderate. Omitting the primary antibody yielded no signal Fig.
The editors will have a look at it as soon as possible. Snouwaert, J.
and Patent Analyst. • Rahbar Rahimpour, PhD. MBA, Senior BDO. • Cheryl Szombati, MA, Compliance Officer. • Jacqueline. Martin Haardt, PhD. UHN. hello. follow.
Message from the Director
edit profile. Profile Views. 0. Followers. 0. Innovations. 4. Activity · Innovations · Publications. TECHNOLOGY We identify the most promising UHN DEVELOPMENT We work with inventors at UHN to. develop the most Martin Haardt, PhD, Business.
The airway epithelium should be accessible by an inhaled vector, and sustained expression of Cftr in a fraction of cells may be sufficient to benefit patients 34.
Video: Martin haardt uhn Celluloid Spaces
Lung Inflammation. USA 97— Examples of each are illustrated in this Report, with indications of where the next round of breakthrough products are likely to emerge. Published online Dec
WASHINGTON COLLEGE DINING HALL HOURS UCONN
|Omitting the primary antibody yielded no signal Fig.
To detect Bcc in the lungs, we probed sections from the above experiment with a polyclonal antibody against Bcc Each point represents the cfu per g lung of an individual mouse, and the horizontal bar represents the median in each group. Snedecor, G. Integrations Wordpress Zapier Dropbox.